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Year Number of Results
1995 1
2001 1
2002 1
2005 1
2006 2
2007 5
2008 1
2010 1
2022 1
2023 2
2024 0

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15 results

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Page 1
Pharmacogenetics of anxiety and depression in Alzheimer's disease.
Cacabelos R, Carril JC, Corzo L, Pego R, Cacabelos N, Alcaraz M, Muñiz A, Martínez-Iglesias O, Naidoo V. Cacabelos R, et al. Pharmacogenomics. 2023 Jan;24(1):27-57. doi: 10.2217/pgs-2022-0137. Epub 2023 Jan 11. Pharmacogenomics. 2023. PMID: 36628952 Review.
The accumulation of defective variants (>30 genes per patient in more than 50% of cases) in pharmagenes (pathogenic, mechanistic, metabolic, transporter, pleiotropic) influences the therapeutic response to antidementia, antidepressant and anxiolytic drugs in polyvalent regimen …
The accumulation of defective variants (>30 genes per patient in more than 50% of cases) in pharmagenes (pathogenic, mechanistic, metabol …
[Role of gene polymorphism of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAOB), cytochrome P450 2D6 (CYP2D6) and N-acetyltransferase 2 (NAT2) in pathogenesis of Parkinson's disease].
Białecka M, Droździk M, Podraza H. Białecka M, et al. Neurol Neurochir Pol. 2002 Jan-Feb;36(1):113-21. Neurol Neurochir Pol. 2002. PMID: 12053603 Review. Polish.
In the search of factors that can precipitate degeneration of dopaminergic neurons the role of enzymes catabolising xenobiotics (CYP2D6, NAT2) and enzymes metabolising catecholamines (COMT, MAO B) has been postulated. ...
In the search of factors that can precipitate degeneration of dopaminergic neurons the role of enzymes catabolising xenobiotics (CYP2D6 …
Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease.
Bialecka M, Klodowska-Duda G, Honczarenko K, Gawrońska-Szklarz B, Opala G, Safranow K, Droździk M. Bialecka M, et al. Parkinsonism Relat Disord. 2007 May;13(4):224-9. doi: 10.1016/j.parkreldis.2006.10.006. Epub 2007 Jan 31. Parkinsonism Relat Disord. 2007. PMID: 17270484
The aim of the present study was to evaluate the contribution of MAOB, COMT, NAT2 and CYP2D6 gene polymorphisms to early onset Parkinson's disease (PD). ...It was shown that neither NAT2, CYP2D6 nor COMT genotype was associated with PD....
The aim of the present study was to evaluate the contribution of MAOB, COMT, NAT2 and CYP2D6 gene polymorphisms to early onset …
In Vitro Evaluation of the Potential for Drug Interactions by Salidroside.
Kasprzyk PG, Tremaine L, Fahmi OA, Weng JK. Kasprzyk PG, et al. Nutrients. 2023 Aug 25;15(17):3723. doi: 10.3390/nu15173723. Nutrients. 2023. PMID: 37686755 Free PMC article.
In this report, we examined the effects of bioengineered, nature-identical salidroside on the inhibition potential of salidroside on CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 utilizing human liver microsomes, the induction potential of salidroside on CYP1 …
In this report, we examined the effects of bioengineered, nature-identical salidroside on the inhibition potential of salidroside on CYP1A2, …
Clinical pharmacokinetics of the monoamine oxidase-A inhibitor moclobemide.
Mayersohn M, Guentert TW. Mayersohn M, et al. Clin Pharmacokinet. 1995 Nov;29(5):292-332. doi: 10.2165/00003088-199529050-00002. Clin Pharmacokinet. 1995. PMID: 8582117 Review.
Cimetidine inhibits the elimination of moclobemide. Moclobemide appears to affect several isoenzymes of the cytochrome P450 (CYP) system (CYP2C19, CYP2D6 and CYP1A2). The adverse events profile of moclobemide indicates only mild and transient effects at a relatively …
Cimetidine inhibits the elimination of moclobemide. Moclobemide appears to affect several isoenzymes of the cytochrome P450 (CYP) sys …
The mechanism of Renshen-Fuzi herb pair for treating heart failure-Integrating a cardiovascular pharmacological assessment with serum metabolomics.
Chen X, Chen Y, Xie S, Wang X, Wu Y, Zhang H, Zhao Y, Jia J, Wang B, Li W, Tang J, Xiao X. Chen X, et al. Front Pharmacol. 2022 Dec 5;13:995796. doi: 10.3389/fphar.2022.995796. eCollection 2022. Front Pharmacol. 2022. PMID: 36545315 Free PMC article.
Through topological analysis of the "Metabolite-Target-Component" interaction network, we found that 79 compounds of RS-FZ directly regulated the downstream specific serum metabolites by acting on four critical target proteins (CYP2D6, EPHX2, MAOB, and ENPP2). The i …
Through topological analysis of the "Metabolite-Target-Component" interaction network, we found that 79 compounds of RS-FZ directly regulate …
Polymorphism in environment responsive genes and association with Parkinson disease.
Singh M, Khan AJ, Shah PP, Shukla R, Khanna VK, Parmar D. Singh M, et al. Mol Cell Biochem. 2008 May;312(1-2):131-8. doi: 10.1007/s11010-008-9728-2. Epub 2008 Mar 9. Mol Cell Biochem. 2008. PMID: 18327668
Multivariate logistic regression analysis revealed that heterozygous genotypes of cytochrome P4502D6*4(CYP2D6*4), CYP2E1*5B (RsaI) polymorphism and homozygous mutant genotypes of CYP2E1*6 (Dra1) were found to be overrepresented in PD cases when compared to the contr …
Multivariate logistic regression analysis revealed that heterozygous genotypes of cytochrome P4502D6*4(CYP2D6*4), CYP2E1*5B (R …
Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.
Herraiz T, Guillén H, Arán VJ, Idle JR, Gonzalez FJ. Herraiz T, et al. Toxicol Appl Pharmacol. 2006 Nov 1;216(3):387-98. doi: 10.1016/j.taap.2006.06.003. Epub 2006 Jun 15. Toxicol Appl Pharmacol. 2006. PMID: 16870220
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin is a chemical inducer of Parkinson's disease (PD) whereas N-methylated beta-carbolines and isoquinolines are naturally occurring analogues of MPTP involved in PD. This research has studied the oxidation of MPTP by hum …
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin is a chemical inducer of Parkinson's disease (PD) whereas N-methylated beta-c …
A case-control study of Parkinson's disease and tobacco use: gene-tobacco interactions.
De Palma G, Dick FD, Calzetti S, Scott NW, Prescott GJ, Osborne A, Haites N, Mozzoni P, Negrotti A, Scaglioni A, Mutti A; Geoparkinson Study Group. De Palma G, et al. Mov Disord. 2010 May 15;25(7):912-9. doi: 10.1002/mds.22980. Mov Disord. 2010. PMID: 20461808
The polymorphisms of genes involved either in metabolism of compounds contained in tobacco smoke (CYP2D6, CYP1B1, GSTM1, GSTT1, GSTM3, GSTP1, NQO1, SOD2, EPHX and NAT2) or in dopaminergic neurotransmission (MAOA, MAOB, DAT1 and DRD2) were characterized by PCR based …
The polymorphisms of genes involved either in metabolism of compounds contained in tobacco smoke (CYP2D6, CYP1B1, GSTM1, GSTT1, GSTM3 …
In vitro metabolism of the analgesic bicifadine in the mouse, rat, monkey, and human.
Erickson DA, Hollfelder S, Tenge J, Gohdes M, Burkhardt JJ, Krieter PA. Erickson DA, et al. Drug Metab Dispos. 2007 Dec;35(12):2232-41. doi: 10.1124/dmd.107.016055. Epub 2007 Sep 19. Drug Metab Dispos. 2007. PMID: 17881661
Its formation was inhibited in human microsomes only by quinidine, a CYP2D6 inhibitor. In incubations with individual cDNA-expressed human cytochromes P450, M2 was formed only by CYP2D6 and CYP1A2, with CYP2D6 activity 6-fold greater than that of CYP1A2. ...O …
Its formation was inhibited in human microsomes only by quinidine, a CYP2D6 inhibitor. In incubations with individual cDNA-expressed …
15 results